DM Plant Regeneration Process EN-02 » Flair Pharma The Knowledge Kit.

OBJECTIVE:
- To lay down the procedure for the Regeneration of a Mixed Bed in a DM plant.

SCOPE:
- This SOP is applicable for the regeneration of a mixed bed in a DM plant.

Regeneration

Table of Contents

SOP Standard Operating Procedure

RO Reverse Osmosis

HDPE High Density Poly Ethylene

QC Quality Control

UV Ultra Violet

PROCEDURE:
- Ensure that the mixed bed and pipelines are clean.
- Open the RO water storage tank outlet valve.
- Open the required valve and start the pump.
- Do the backwash for 15 minutes.

Regeneration of mixed bed with sodium hydroxide. (NAOH)
- Take 40 ltrs. RO water from the RO tank in an HDPE container and add 4 kg of sodium hydroxide (NaOH) and Mix with the help of a rod.
- Insert the ejector tube in HDPE container containing sodium hydroxide solution.
- Open the required valve & start the Feed water pump at the pressure of 1 to 2 kg/cm².
- After starting the pump, pass out all NAOH solution through a mixed bed. Its take approx 15 to 20 minutes. After completion of the process, allow slow rinsing with RO water for about 05 to 10 minutes.
- After completion of slow rinsing, switch off the motor and close the valve no. and open the required valve.
- Now start the pump and allow the fast rinsing with RO water for 05 to 10 minutes.

Regeneration of mixed bed with Hydrochloric acid.
- Take 36 ltrs. RO water from RO tank in HDPE container & add 12 ltrs. hydrochloric acid with stirring.
- Insert the Ejector tube in HDPE container containing hydrochloric acid.
- Open the required valves & close other valves.
- Open the RO water valve & switch on the pump.
- After start the pump allow to pass out all hydrochloric acid solution through mixed bed. Its take approx 15 to 20 minutes. After completion of process, & allow rinsing with RO water about 05 to 10 minutes.
- After completion of slow rinsing, switch off the motor and close the valve no. 3, 5 and open the valve no. 4.
  - Now start the pump and allow the fast rinsing with RO water for 05 to 10 minutes.
  - Stop the in feed motor and closed all valve.
  - Mixing of Resin with air.
- Open the 07 and 12 No.valve.
- Pass the compressed air at low pressure (0.7 kg/cm2) through mixed bed for 10 to 15 minutes.
- Open the required valve and Switch ON the feed water pump and run the water through the mixed bed and check the conductivity.
- The conductivity shall be less than 1.3 µS/cm.
- Now open the valve no. 06 and close the valve no. 13 & 14
- Start UV light hour meter counter and conductivity meter.

Check the conductivity of water it should be NMT 1.3 µS/cm. if the conductivity of water is more than the specified limit then repeat the points 6.4, 6.5 & 6.6.

Maintain the regeneration record in Annexure – I “Mixed Bed Regeneration Record”.

Maintain the Mixed Bed Regeneration Output Record in Annexure – II “Mixed Bed Output Record”.

Regeneration

ANNEXURES NO.	TITLE OF ANNEXURE	FORMAT NO.
Annexure-I	Mixed Bed Regeneration Record	EN-0XX/FYY-00
Annexure-II	Mixed Bed Output Record	EN-0XX/FYY-00

DISTRIBUTION:
- Controlled Copy No. 1 Head Engineering
- Master Copy Quality Assurance Department

Not applicable

Revision No.	Change Control No.	Details of Changes	Reason for Change	Effective Date	Updated By
00	CC/XX/XXX	Preparation of New SOP

MIXED BED REGENERATION RECORD
Date	Qty. of NaOH for Regeneration	Qty. of water added	Regeneration detail		Qty. of HCL for Regeneration	Qty. of water added	Regeneration detail		Done by	Checked by Sign & Date
Date	Qty. of NaOH for Regeneration	Qty. of water added	From	To	Qty. of HCL for Regeneration	Qty. of water added	From	To	Done by	Checked by Sign & Date

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